Figure 4. Hb α X peptide decreases systemic blood pressure.
a, Radio telemetry measurements of systolic, diastolic and mean arterial blood pressure from mice injected with various doses of Scr X or Hb α X peptide (0.5–20 mg/kg) in C57BL/6. b, time course of systolic, diastolic and mean arterial blood pressure from C57BL/6 mice injected with a single bolus of 5 mg/kg Scr X or Hb α X daily. c, Systolic, diastolic and mean arterial blood pressure from eNOS−/− mice injected with saline, 5 mg/kg Scr X or Hb α X. * indicates significant differences using a t-test (a,b) and ^ shows significance using a 2-Way ANOVA (a). In c, statistical differences were analyzed using a 1-way ANOVA followed by a Bonferroni’s post-hoc test. n≥4 mice for all conditions; error bars indicate s.e.m.