TABLE III.
Power of different designs for CMC-based analysis strategy
| Power |
||||
|---|---|---|---|---|
| # of causal variants | Variance contribution per SNP (%) | Random sample | Case-control sample | Extreme sample |
| 10 | 0.2 | 0.190 | 0.118 | 0.655 |
| 20 | 0.1 | 0.298 | 0.156 | 0.816 |
We assume there are 100 SNPs with MAF<0.01 in the gene-region, 10 or 20 of which are causal. The causal SNPs are assumed to contribute equally to the phenotypic variance with a total variance contribution of 0.02. Sample sizes for different designs are all set to 800 individuals.