Fig. 5.
MPs from donor ECs treated with TNF-α or TNF-α plus ROCK inhibitor have diminished capacity to transfer miR-155 to recipient ECs, which is abrogated by caspase inhibitor. MPs were isolated from donor ECs that had been untreated (control) or treated with TNF-α with and without caspase and ROCK inhibitor for 24 h. Different groups of donor MPs were incubated with recipient ECs for 2 h. MiRNA-155 levels are expressed relative to recipient ECs incubated with MPs from control donor cells. x-Axis indicates different donor cell treatments. NS, not significant. *P < 0.05 vs. control; #P < 0.05 between groups, n = 3.