Figure 5.
eIF5A proteins are sufficient and necessary for orthotopic PDAC tumor growth. PANC1 (A) or 779E (B) cells expressing control (Ctrl), eIF5A1 (5A1), or eIF5A2 (5A2) shRNAs were orthotopically implanted into athymic mice and allowed to form tumors for 23 days and 16 days, respectively. Bar graphs represent the average tumor weights for each group. C, PANC1 cells overexpressing eIF5A1 (5A1), eIF5A2 (5A2), or mock-transfected (Ctrl) PANC1 cells were orthotopically implanted and allowed to form tumors for 55 days. The average tumor weight from each group was measured as above. * represents P values of < 0.05 as determined by Student's t-test.