Table 5.
Multivariable analysis of predictive factors for relapse following thiopurine withdrawal: final Cox proportional hazards model. (a) Crohn's disease; (b) Ulcerative colitis
| Analysis as continuous variables | Analysis as categorical variables | ||||
|---|---|---|---|---|---|
| Variable | Hazard ratio (95% confidence interval) | P-value | Optimum threshold to split data | Hazard ratio when split by threshold (95% CI) | P-value when split by threshold |
| (a) | |||||
| White cell count | 1.18 (1.04–1.33) | 0.011 | ≥6.6 × 109/L | 3.75 (1.87–7.54) | 0.0002 |
| C-reactive protein | 1.04 (1.00–1.07) | 0.035 | ≥14 g/L | 3.2 (1.48–7.05) | 0.003 |
| (b) | |||||
| White cell count | 1.44 (1.11–1.87) | 0.007 | ≥9.1 × 109/L | 6.70 (1.86–24.2) | 0.004 |