Skip to main content
. Author manuscript; available in PMC: 2015 Apr 16.
Published in final edited form as: Nature. 2014 Sep 24;514(7522):385–388. doi: 10.1038/nature13813

Figure 3. Effects of cone precursor circuitry on response to Rb depletion.

Figure 3

a, Prevalence of Ki67+ or CC3+ cells (top) and cell numbers (bottom) after shRNA transduction of isolated cone precursors. b, Isolated cone precursor response to co-transduction with shRB1 and BN vector, BN-p130, or BN-SKP2. c–e, Effect of p130 overexpression or p107 knockdown on Y79 proliferation (c, d) and protein expression (e). Compared to scrambled and vector controls: *, p < 0.01. #, p < 0.05. Compared to shRB1 + SCR (a) or to shRB1 + BN (b): $, p < 0.01. &, p < 0.05. Results represent at least two independent experiments.