. 2014 Jun 12;11:46. doi: 10.1186/1742-4690-11-46

Table 1.

Proteome of F12/HIV-1^a

*Viral gene*	*Amino acid substitutions*	*Viral protein product*
*gag*	p17: 1	Inefficient cleavage of the p55 precursor [12,13]
	p24: 6
	p15: 3
*pol*	Pro: 3	Apparently intact [12]
	RT: 10
	Endo: 2
*env*	gp120: 4	No cleavage of the gp160 precursor [11,12]
	gp41: 2
*nef*	3	Defects in trafficking and signaling functions [13,14]
*tat*	0	Functional [12]
*rev*	0	Functional [12]
*vif*	14	Functionally defective [12,15]
*vpr*	3	Premature stop codon at aa 76 [12]
*vpu*	0	Apparently intact [12]

^aThe F12/HIV-1 amino acid sequence was compared to a consensus sequence obtained with multiple alignments of 5 type B HIV-1 isolates. No nucleotide substitutions have been found in the LTRs, TAR, and RRE HIV-1 regulatory sequences.