TABLE 4.
Performance of Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Serum Signature (Seven Features) to Distinguish Cases of Lung Cancer from Matched Controls After Two Methods of Analysis: the Weighted Flexible Compound Covariate Method (WFCCM) and Support Vector Machine (SVM)
| Training Set
|
Test Set
|
|||
|---|---|---|---|---|
| WFCCM | SVM | WFCCM | SVM | |
| Cases | 92 | 92 | 50 | 50 |
| Controls | 90 | 90 | 56 | 56 |
| Accuracy (95% CI) | 78.0 (72, 84) | 81.32 | 72.6 (64, 81) | 79.25 |
| Sensitivity (95% CI) | 67.4 (58, 77) | 70.00 | 58.0 (44, 72) | 64.00 |
| Specificity (95% CI) | 88.9 (82, 95) | 93.33 | 85.7 (77, 95) | 92.86 |
| Misclassified cases | 30 | 28 | 21 | 18 |
| Misclassified controls | 10 | 6 | 8 | 4 |