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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Epidemiology. 2014 Sep;25(5):749–761. doi: 10.1097/EDE.0000000000000121

Table 1.

The Four Basic Components of the Total Effect (the following four components sum to the total effect TE = Y1 − Y0)

Effect Counterfactual Definition Empirical Analogue Interpretation
Controlled Direct Effect (CDE) (Y10 − Y00) (p10 − p00) Due Neither to Mediation nor Interaction
Reference Interaction (INTref) (Y11 − Y10 − Y01 + Y00)(M0) (p11 − p10 − p01 + p00)P(M = 1|A = 0) Due to Interaction Only
Mediated Interaction (INTmed) (Y11 − Y10 − Y01 + Y00)(M1 − M0) (p11 − p10 − p01 + p00){P(M = 1|A = 1) − P(M = 1|A = 0)} Due to Mediation and Interaction
Pure Indirect Effect (PIE) (Y01 − Y00)(M1 − M0) = (Y0M1 − Y0M0) (p01 − p00){P(M = 1|A = 1) − P(M = 1|A = 0)}. Due to Mediation Only