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. Author manuscript; available in PMC: 2014 Oct 14.
Published in final edited form as: Annu Rev Biochem. 2007;76:387–417. doi: 10.1146/annurev.biochem.75.103004.142819

Figure 2.

Figure 2

The TRP domain. Highly conserved region of 23–25 amino acids C-terminal to the transmembrane domains in TRPCs, TRPNs, and TRPMs. TRP box 1 is invariant in TRPCs, and variations of TRP box 1 are also present in TRPNs and TRPMs. The TRP box 2 is a proline-rich region. Sequences are from mammals, except zTRPN1 is from zebrafish; cNOMPC is from Caenorhabditis elegans; and TRP, TRPL, TRPγ, and dTRPM are from Drosophila.