Figure 7.
Injection of orexin-A (OX-A) and orexin-B (OX-B) in the anterior paraventricular thalamus (aPVT) but not posterior paraventricular thalamus (pPVT) increases intermittent-access 20% ethanol drinking. A. Ethanol drinking in rats injected in the aPVT with 0.3 µl OX-A (1.0, 0.5 nmol) or saline vehicle (Set 4, n = 8). B. Drinking in rats injected in the aPVT with 0.3 µl OX-B (1.0, 0.5 nmol) or saline vehicle (Set 4, n = 8). C. Ethanol drinking in rats injected in the pPVT with OX-A or saline vehicle (Set 4, n = 7). D. Drinking in rats injected in the pPVT with OX-B or saline vehicle (Set 4, n = 7). Effects were no longer evident at four hours post-injection (data not shown). *p < 0.05, #p = 0.06 vs. vehicle.
