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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Cell Metab. 2014 Oct 7;20(4):565–572. doi: 10.1016/j.cmet.2014.09.002

Figure 3. A dual component lipostatic model.

Figure 3

(A) Kennedy proposed a single satiety factor capable of inducing catabolic and anabolic effects in response to weight loss and gain, respectively (B) Leptin, at reduced concentrations acts as a powerful anabolic factor regulating metabolic/behavioral responses to weight loss. (C) We propose that a catabolic factor similarly regulates the response to overfeeding, augmented weight and increased fat mass.