Table 4.
Odds ratio (and 95% confidence interval) for IVH without and with accompanying WMI among children who had the concentration in the top quartile (for gestational age and day specimen was obtained) of the protein(s) listed on the left on one or at least two days relative to that of children who did not have an elevated concentration of the same protein(s). The sample for these analyses consists of children who had proteins measured in blood collected on two separate days. The models are adjusted for gestational age (23-24, 25-26, 27 weeks). Odds ratios significant at p < .01 are in bold.
| IVH unaccompanied by WMI | IVH accompanied by WMI | |||
|---|---|---|---|---|
| 1 day only | > 2 days | 1 day only | > 2 days | |
| CRP* | 1.2 (0.6, 2.1) | 1.6 (0.8, 3.1) | 1.3 (0.5, 3.4) | 3.7 (1.6, 8.7) |
| SAA | 0.8 (0.5, 1.5) | 1.1 (0.5, 2.2) | 2.2 (0.9, 5.1) | 3.4 (1.4, 8.6) |
| MPO | 1.2 (0.6, 2.2) | 1.5 (0.8, 3.0) | 0.7 (0.3, 1.6) | 1.3 (0.5, 3.1) |
| IL-1β | 1.0 (0.6, 1.8) | 1.0 (0.4, 2.1) | 2.1 (0.9, 4.8) | 2.8 (1.1, 7.4) |
| IL-6 | 1.3 (0.7, 2.2) | 1.4 (0.7, 2.8) | 1.8 (0.8, 4.2) | 2.8 (1.1, 7.0) |
| IL-6R | 1.0 (0.6, 1.9) | 0.9 (0.4, 1.8) | 0.9 (0.4, 2.2) | 0.7 (0.2, 1.8) |
| TNF-α | 1.1 (0.6, 2.1) | 1.8 (0.9, 3.6) | 1.1 (0.4, 2.7) | 4.0 (0.7, 9.2) |
| TNF-R1 | 0.9 (0.5, 1.7) | 1.3 (0.7, 2.6) | 1.8 (0.8, 4.0) | 1.9 (0.7, 4.9) |
| TNF-R2 | 1.0 (0.6, 1.9) | 1.2 (0.6, 2.5) | 1.2 (0.5, 2.9) | 1.9 (0.8, 4.7) |
| IL-8 (CXCL8) | 1.4 (0.8, 2.6) | 2.5 (1.2, 5.1) | 3.5 (1.3, 9.3) | 11 (3.9, 29) |
| MCP-1 (CCL2) | 1.7 (0.9, 3.0) | 1.8 (0.9, 3.6) | 1.5 (0.6, 3.5) | 2.9 (1.2, 7.0) |
| MCP-4 (CCL13) | 0.8 (0.4, 1.5) | 1.0 (0.5, 1.9) | 2.3 (1.03, 5.3) | 1.6 (0.6, 4.1) |
| MIP-1B (CCL4) | 1.2 (0.7, 2.3) | 1.1 (0.5, 2.2) | 1.1 (0.5, 2.8) | 2.4 (1.03, 5.6) |
| RANTES (CCL5) | 1.1 (0.6, 2.0) | 0.8 (0.4, 1.7) | 0.9 (0.4, 2.0) | 0.6 (0.2, 1.7) |
| I-TAC ( CXCL11) | 1.1 (0.6, 2.0) | 1.2 (0.6, 2.4) | 1.0 (0.4, 2.3) | 1.7 (0.7, 4.0) |
| ICAM-1 (CD54) | 0.9 (0.5, 1.6) | 1.3 (0.7, 2.6) | 1.5 (0.6, 3.6) | 3.8 (1.6, 9.0) |
| ICAM-3 (CD50) | 1.7 (0.9, 3.2) | 1.8 (0.9, 3.4) | 2.4 (1.01, 5.6) | 2.2 (0.9, 5.5) |
| VCAM-1 (CD106) | 1.5 (0.8, 2.7) | 1.6 (0.8, 3.1) | 1.0 (0.4, 2.4) | 1.0 (0.4, 2.6) |
| E-SEL (CD62E) | 1.2 (0.7, 2.2) | 1.3 (0.6, 2.6) | 1.3 (0.5, 3.1) | 2.2 (0.9, 5.3) |
| MMP-1 | 1.1 (0.6, 2.2) | 1.6 (0.8, 2.9) | 0.9, 0.3, 2.3) | 1.1 (0.5, 2.8) |
| MMP-9 | 1.7 (0.9, 3.0) | 1.7 (0.9, 3.6) | 1.4 (0.7, 3.2) | 1.5 (0.6, 4.1) |
| VEGF | 1.0 (0.5, 1.8) | 1.0 (0.5, 1.9) | 1.7 (0.7, 4.0) | 2.1 (0.9, 4.9) |
| VEGF-R1 | 0.8 (0.4, 1.5) | 1.1 (0.6, 2.3) | 2.2 (0.9, 5.1) | 2.4 (0.9, 6.2) |
| VEGF-R2 | 0.9 (0.5, 1.7) | 1.5 (0.8, 2.8) | 1.2 (0.5, 2.8) | 1.6 (0.7, 4.0) |
| IGFBP-1 | 1.4 (0.8, 2.5) | 0.9 (0.4, 2.1) | 1.5 (0.6, 3.4) | 2.8 (1.1, 7.2) |
*
For abbreviations, see methods section of text.