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. Author manuscript; available in PMC: 2015 Jan 29.
Published in final edited form as: Nat Commun. 2014 Jul 29;5:4510. doi: 10.1038/ncomms5510

Figure 5. Gene ontology enrichment analysis reveals unexpected classes of ribosome-bound dendritic transcripts.

Figure 5

(a) Classification of somatic mRNAs by machine learning analysis of contextual fear conditioning somatic RNA-Seq data (green = somatic, brown = background). (b) Gene ontology (GO) enrichment analysis of dendritic and somatic mRNAs.In agreement with previous studies 27,28 , dendritic mRNAs were highly enriched in translation and cytoskeleton GO categories. Unexpected GO categories with dendritic mRNA enrichment included chromosome organization and transcription factor binding. GO categories that include the Pafah1b1 gene, Mediator genes, and H4 histone genes are indicated. Venn diagram insets show the number of unique histone H4 and Mediator mRNAs that were detected in the RNA-Seq data as well as their classifications. Also see Supplementary Fig.4.