FIGURE 3.
Estrogen regulation on LIF and STAT3 in mouse uterus. A, LIF mRNA level was induced by estrogen at 3 h. Pretreatment with ICI attenuated the effect of estrogen on LIF induction. B, STAT3 mRNA expression level in ovariectomized mouse uterus was induced at 3 h after estrogen treatment. ICI treatment blocked the estrogen up-regulation on Egr1. C, PPT treatment up-regulates the LIF mRNA level in ovariectomized mouse uterus. D, STAT3 mRNA expression level was induced by PPT treatment. E, estrogen regulation on LIF in ERαKO mice uteri. F, estrogen regulation on STAT3 in ERαKO mice uteri. G, Western shows that STAT3 was activated after estrogen treatment in WT littermates but not ERαKO mice uteri. *, p < 0.05.