Table 1.
Summary of inflammasome scaffolds and their links to SLE.
| Inflammasome Scaffold | Activation Triggers | Links to SLE |
|---|---|---|
| NLRP1 | Bacillus anthracis lethal toxin | Genetic polymorphisms associated with SLE |
| NLRP3 | Crystalline material, potassium efflux, immune complexes, C3a, UVB radiation, microbial PAMPs, mitochondrial destabilization | Upregulated in diseased tissue, inhibition improves disease in murine models |
| NLRC4/IPAF | Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila, Shigella flexneri infection | None reported |
| AIM2 | Double-stranded DNA; DNA viruses, Francisella tularensis and Listeria monocytogenes infection | Inhibition provides resistance to apoptotic DNA-induced lupus phenotype but also increases type I IFN responses through upregulation of p202 |
| IFI-16 | DNA | None reported |
| RIG-I | RNA | May facilitate CCL5 upregulation in nephritis but no links with its inflammasome activity known |
CCL5=chemokine ligand 5, PAMPs=pathogen-associated molecular patterns, SLE=systemic lupus erythematosus