Figure 7.
Whisker and paw sensation is impaired in ThNR1KO mice. In the gap-crossing test, ThNR1KO mice cross shorter gap distances than controls (NR1flox/flox) both in the light (t(14) = 5.73782, p < 0.001) and in the dark (infrared) condition (t(10) = 3.4295, p = 0.0063). In the edge-approach test, ThNR1KO mice reach a shorter distance compared with control mice (t(14) = 8.6346, p < 0.0001). In the swimming test, ThNR1KO mice show a similar level of paddling (t(14) = 0.2614, p = 0.797), but significantly shorter floating time than controls (t(14) = 8.8859, p < 0.0001). ThNR1KO mice display a longer latency for licking a sticky paper off their hindpaw than controls (t(8) = 3.231, p = 0.012). In the grid-walking test, ThNR1KO mice show lower correct step ratio than controls for both the forepaws (t(14) = 4.2037, p = 0.0009) and the hindpaws (t(14) = 4.62988, p = 0.0004). In the bridge-walking test, ThNR1KO mice show significantly longer duration for reaching a platform than controls (two-way ANOVA: strain F(1,14) = 81.616, p < 0.0001; trial F(2,28) = 5.141, p = 0.0125; and strain × trial F(2,28) = 1.373, p = 0.2699). However, in the wire hanging test, there was no significant difference in hanging duration (t(14) = 0.0435, p = 0.9659) between the ThNR1KO and the control mice.