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. Author manuscript; available in PMC: 2014 Aug 29.
Published in final edited form as: Cell. 2007 Apr 6;129(1):195–206. doi: 10.1016/j.cell.2007.01.050

Figure 7. A model for control of long-term synaptic plasticity and memory by eIF2α phosphorylation.

Figure 7

Under basal conditions, general translation is reduced and ATF4 mRNA translation is augmented, due to partial phosphoryation of eIF2α. As a consequence, expression of synaptic plasticity and memory-related genes is depressed, late-LTP has a high threshold and mnemonic function is poor. Decreased eIF2α phosphorylation reduces ATF4 mRNA translation and enhances general mRNA translation, thus facilitating the induction of gene expression which leads to L-LTP and long-term-memory (LTM) consolidation.