Figure 6. Long term treatment with 1NMPP1 treatment exerts no detectable antiseizure effect in naïve TrkBF616A mice.
(A) Per protocol depicted in Figure 1D, TrkBF616A mice were treated with 1NMPP1 or vehicle for 10 days prior to measurement of EST. Thresholds were 128±26 µA and 103±12 µA for vehicle- (n=6) and 1NMPP1-treated (n=7) TrkBF616A mice respectively (t-test, p>0.05). (B) Per protocol depicted in Figure 1E, the initial EST was measured in absence of treatment in TrkBF616A mice, after which 1NMPP1 or vehicle was administered for 2 weeks, at which time seizure threshold was measured a second time. The ratios of post-treatment EST to pre-treatment EST were 1.13±0.13 for 1NMPP1- and 1.19±0.76 for vehicle-treated mice, respectively (t-test, p>0.05).