Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The shift of p53 mutations in colitis-associated colorectal cancer. Being a late mutational event in sporadic and familial colon cancer, the p53 mutation appearance is changed when chronic inflammation is a preceding condition in the tissue, becoming an early event. Such mutations switch their tumor-promoting properties to tumor-initiating properties, leading to colon tumorigenesis through a different path.
