Table 5.
Clinical characteristics of the PTEN hamartoma tumor syndrome
| Clinical characteristics |
| Benign neoplasia |
| Dermatologic |
| Palmoplantar keratoses |
| Trichilemmomas |
| Lipomas |
| Fibromas |
| Freckling of the glans penis |
| Vascular anomalies/hemangiomas |
| Lhermitte-Duclos (dysplastic gangliocytoma of the cerebellum) |
| Genitourinary tumors/malformations |
| Colorectal polyposis |
| Mucosal lesions |
| Thyroid goiter/nodules |
| Proliferative breast changes |
| Malignant neoplasia |
| Breast cancer |
| Non-medullary thyroid cancer |
| Renal cancer |
| Endometrial cancer |
| Colorectal cancer |
| Melanoma |
| Central nervous system |
| Macrocephaly |
| Autism/developmental delay |
| Dysmorphic characteristics |
| Dolichocephaly |
| Postaxial polydactyly |