Skip to main content
. Author manuscript; available in PMC: 2015 Jun 19.
Published in final edited form as: Immunity. 2014 May 29;40(6):880–895. doi: 10.1016/j.immuni.2014.04.018

Figure 1. TRIM6 enhances induction of IFNβ but not NF-kB-dependent cytokines.

Figure 1

(A-B) HEK-293T cells were transfected with the ISG54 IFN-stimulated responsive element (ISRE) or NF-kB reporter plasmid together with TRIM6 or TRIM25 and stimulating plasmids or SeV as indicated, followed by luciferase assay. Data are representative of 3 independent experiments and depicted is the mean ± SD (n=3). (C-E) hDCs transduced with lentiviruses expressing TRIM6 shRNAs were stimulated with LPS. At 2 h p.t. cells were harvested for RT-qPCR and plotted as percentage of control or fold induction over mock-induced samples. See also Figure S1.