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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Neuropharmacology. 2014 May 27;85:232–242. doi: 10.1016/j.neuropharm.2014.05.027

Figure 2. SGE201 accelerates rate of MK-801 block and potentiates whole cell NMDA current equivalently.

Figure 2

A. Responses from a hippocampal neuron to saturating NMDA application (1 mM) in the absence and presence of SGE201 (2 μM). B. Currents to NMDA (1 mM) in the absence and presence of 24(S)-HC (10 μM). C. Response to 300 μM NMDA and MK-801 (5 μM onset) in a control cell (black trace; N = 10) and a sibling culture pre-incubated with 2 μM SGE201 (red trace; N = 10). D. Representative traces indicating responses from a neuron to a saturating NMDA (300 μM) application (Black: saline; Red: SGE201, 2 μM; N = 10). E. Normalized change in whole-cell current and the change in weighted rate constant (Arrows in C) of MK-801 block derived from C and D. There was no significant difference between the two measurements (p = 0.46, unpaired t-test). Whiskers represent 10th and 90th percentiles. The box boundaries represent 25th and 75th percentiles. The lines within the boxes mark the median value.