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. Author manuscript; available in PMC: 2014 Oct 3.
Published in final edited form as: Nature. 2014 Mar 23;508(7494):103–107. doi: 10.1038/nature13119

Figure 4. XBP1 genetic signature is associated with human TNBC prognosis.

Figure 4

a, Heatmap showing the expression profile of genes bound by XBP1 and differentially expressed after XBP1 knockdown. b,c, Kaplan-Meier graphs demonstrating a significant association between elevated expression of the XBP1 signature (red line) and shorter relapse free survival in two cohorts of patients with TNBC (b, and c). d, Kaplan-Meier graphs showing significant association of elevated HIF1α gene signature expression (red line) with shorter relapse free survival in a cohort of 383 TNBC patients. The log-rank test P values are shown.