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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Gastroenterology. 2014 Mar 20;146(7):1763–1774. doi: 10.1053/j.gastro.2014.03.014

Figure 2.

Figure 2

Lactate suppresses TLR primed NLRP3 inflammasome activity. Murine peritoneal macrophages were treated with LPS, ATP, and lactate, and then assessed for CASP1 cleavage to the P10 subunit in Western blots (A), caspase 1 activity (B), and IL1b release into the supernatant (C). Human peripheral blood mononuclear cells treated with LPS, ATP, and lactate and assessed for IL1brelease (D). Asterisks denote significant difference (P<0.05) between treatment groups.