Figure 2.
Arrest in development in End–/– embryos. β-gal expression driven by the End promoter was analyzed in whole End+/– and End–/– embryos. At E9.0, embryos are of similar size and their vasculature appears normal. The End–/– embryo shows an enlarged heart protruding forward (arrowhead). At E9.5, edematous pericardium (arrowhead) is observed in the End–/– embryo, which is growth-retarded compared with the End+/– embryo. At E10.5, the End –/– embryo is dead and is much smaller that the End+/– embryo. Bar: 500 μm.