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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Hum Genet. 2013 Nov 1;133(3):357–365. doi: 10.1007/s00439-013-1388-y

Table 1.

Results of the overall and sub-group allelic analyses

SNPs / Groups Studiesa Samplesb LnOR (95% CI) OR (95% CI) P(Z) P(Q)
HTR2A rs6313 (102T/C)
All the studies 13 1,407/1,908/35 −0.16 (−0.26, −0.05) 0.86 (0.77,0.95) 0.0048 0.23
Europeans 4 326/155/35 −0.35 (−0.61, −0.09) 0.7 (0.54,0.91) 0.0074 0.34
Asians 9 1,081/1,753 −0.11 (−0.23,0.01) 0.89 (0.79,1.01) 0.062 0.34
Alcohol dependence/abuse 9 715/503/35 −0.34 (−0.52, −0.17) 0.71 (0.59,0.85) 0.0001 0.47
Alcohol dependence/abuse (Asians) 5 389/348 −0.34 (−0.58, −0.1) 0.71 (0.56,0.91) 0.0063 0.37
All the studies & SAGEc 15 3,098/3,620/35 −0.11 (−0.19, −0.04) 0.89 (0.83,0.96) 0.0023 0.29
Europeans & SAGEc 5 1,440/1,437/35 −0.11 (−0.22, −0.01) 0.89 (0.8,0.99) 0.0338 0.12
Alcohol dependence/abuse & SAGEc 11 2,406/2,215/35 −0.14 (−0.23, −0.05) 0.87 (0.8,0.95) 0.0013 0.15
HTR2A rs6311 (-1438A/G)
All the studies 12 2,760/3,056 0.06 (−0.06,0.19) 1.07 (0.94,1.21) 0.3263 0.0071
Europeans & Hispanic 3 359/623 0.42 (0.22,0.61) 1.51 (1.24,1.85) 4×10−5 0.98
Asians 9 2,401/2,433 −0.05 (−0.13,0.04) 0.95 (0.87,1.04) 0.2957 0.41
Heroin dependence/abuse 7 1,770/1,578 0.08 (−0.03,0.18) 1.08 (0.97,1.2) 0.149 0.21
Alcohol dependence/abuse 4 794/676 0.12 (−0.27,0.51) 1.13 (0.76,1.66) 0.5478 0.0016
Alcohol dependence/abuse (Europeans) 2 246/203 0.42 (0.15,0.68) 1.52 (1.16,1.98) 0.0023 0.83
Alcohol dependence/abuse (Asians) 2 548/473 −0.22 (−0.4, −0.04) 0.81 (0.67,0.96) 0.0176 0.56
All the studies & SAGEc 14 4,451/4,768 0.03 (−0.08,0.13) 1.03 (0.93,1.14) 0.6283 0.0063
a

, the number of studies included are indicated.

b

, the number of cases/controls/families. The 35 families included 116 subjects.

c

, 1,691 cases and 1,712 controls from the Study of Addiction: Genetics and Environment (SAGE) datasets (European and African Americans) were included in the meta-analysis.

P(Z): Z test used to determine the significance of the overall OR. The P values < 0.05 are indicated in red boldfaces.

P(Q): Cochran’s X2-based Q statistic test used to assess the heterogeneity.

P(T): T test used to estimate the significance of publication bias (not shown).