Table 1. Multiple bacterial strains contribute to colitis.
Multiple bacterial species are capable of contributing to or inducing colitis in mice depending on the experimental conditions and background strain. There is no single common species across all models, indicating that the resulting IBD depends on not only on genotype but also on the local environment, particularly the microbiota composition in different facilities.
| Model | Organism | Mouse Strain | Publication |
|---|---|---|---|
| CD45RBhi | SFB + others | BALB/cJHanHsd-SCID | Stepankova et al. 2007 |
| CD4-dnTgfβ × IL- 10R2−/− | Bacteroides | C57BL/6 | Bloom et al. 2011 |
| IL-10−/− | Clostridia XIVa Lachnospiraceae |
C3H/HeJBir | Duck et al. 2007 |
| TRUC | K. pneunomiae P. mirabilis |
Balb/c × Rag2−/− × Tbet−/− | Garrett et al. 2007 |
| DSS NLRP6−/− | Prevotellaceae TM7 |
C57BL/6 | Elinav et al. 2011 |
| IL-10−/− | E.coli E. faecalis |
129S6/SvEv | Kim et al. 2005 |