Figure 4.
Effect of vitamin E on MAPT methylation. A + B) Scatter plots of vitamin E versus MAPT methylation levels in individuals segregated by their diplotype status as H1 (H1/H1 homozygotes) and H2 carriers (H1/H2 heterozygotes and H2/H2 heterozygotes). C) Dose response effect of vitamin E on either the H1 (open bar) or H2 (grey bar) of MAPT in SK-N-F1 cells. Methylation levels of each replicate were normalized against the value observed for the H1 haplotype at 0 mM vitamin E. Error bars indicate standard error of the mean from five independent experiments * = p < 0.05, ** = p < 0.001.