FIG. 7.
Motor handicap (the UPDRS motor score) over the course of DFP treatment in a delayed-start paradigm (Supplementary Fig. S1). Details of the dopaminergic drug treatments are provided in Supplementary Table S1 and did not change during the course of the study. Left part: Mean±SEM change after 6 to 12 months of treatment (relative to baseline): early-start (ES) group: n=20; delayed-start (DS) group: n=19; *significant difference at 6 months: p=0.002; at 12 months: p=0.04, according to a baseline-adjusted covariance analysis. Right part: Mean±SEM change between 18 and 24 months: early cessation (EC) group: n=18; delayed cessation (DC) group: n=16; *significant difference p=0.003, according to a covariance analysis adjusted for the month 18 visit.