Figure 3. IRF4 controls essential gene expression programs in ABC DLBCL.
(A) IRF4 direct target genes grouped according to gene expression signatures (Shaffer et al., 2006). Signatures with significant enrichment for IRF4 targets were grouped by function (Table S3A). Genes that are induced or repressed by IRF4 are indicated in green and red, respectively. Asterisks indicate genes with an overlapping IRF4-SPIB ChIP-seq peak. (B) ISRE-driven luciferase reporter activity in ABC DLBCL lines with control or IRF4 shRNAs after 2 days of induction and subsequent addition of IFNβ (1000U). Error bars show the SEM of triplicates. See also Figure S3 and Table S3.