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. Author manuscript; available in PMC: 2015 Mar 12.
Published in final edited form as: Cell Host Microbe. 2014 Mar 12;15(3):382–392. doi: 10.1016/j.chom.2014.02.005

Figure 5. A view of the microbial composition across different IBD cohorts.

Figure 5

We combined microbial profiles obtained for 1,742 subjects from three different IBD cohorts and generated a set of principal coordinate plots of the unweighted UniFrac distance, where each sample was colored by (A) cohort, (B) disease type, (C) MD-index, or (D) species richness (Chao1). From this combined view, it is clear that the first principal coordinate (PC1) stratifies the samples by species richness, which is negatively correlated with MD-index, and that the second principal coordinate (PC2) is largely affected by cohort. Disease phenotype is no obvious driver for sample clustering.