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Pharmacokinetic parameters for lead compound 5
| Route |
Dose |
Cmax
|
Tmax
|
Area under the Curve |
CL/F |
t1/2
|
|---|---|---|---|---|---|---|
| µg/kg | pg/ml | hr | pg × h/ml | l/h/kg | h | |
| i.v. | 20 | 2230 | 0.08 | 1704 | 11.73 | 1.9 |
| i.v. | 50 | 7790 | 0.08 | 3559 | 14.05 | 1.5 |
| Oral | 200 | 89 | 2 | 578 | 346 | 3.4 |
CL, clearance; F, bioavailability.
