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Pattern of atrophy in low-risk healthy elderly persons. Annual atrophy was standardized for each group, yielding maps showing areas of more (blue-cyan) versus less (red-yellow) relative atrophy expressed in units of SDs (z-scores). As can be seen, the pattern of atrophy is distinctly frontotemporal, with some evidence of medial parietal atrophy (precuneus/retrosplenial cortex) as well. Abeta indicates amyloid-β; APOE, apolipoprotein ε4.
