Figure 2. Diet Induced Enhancer Alterations in Colonic Epithelium Resemble the Enhancer Signature of Colon Cancer.
(A) Tissue specificity of differentially enriched H3K27ac regions. Tissue-specificity scores (Q-Statistic, Y axis) for H3K27ac signals in 10 different tissues are plotted for gained (left panels) and lost (right panels) H3K27ac regions in female mice (upper panels) and male mice (lower panels). (B) De novo discovery of motifs associated with differential H3K27ac regions. The HOMER package (version 4.1) was used to search for de novo DNA sequence motifs. The motifs were then assigned to transcription factors or transcription factor families based on similarity with known motif matrices. In addition, the fraction of H3K27ac regions containing the motifs and p-value for the overrepresentation of each motif were shown. See also Figure S2 and Table S2.