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MLS000544460 is a reversible inhibitor. 1 nm Eya2 ED incubated with various concentrations of MLS000544460 demonstrates that the IC50 of MLS000544460 is ∼4 μm under this condition (first three columns in each panel). The enzymatic activity of Eya2 ED at 1 or 3 h following a 100-fold dilution of 100 nm Eya2 ED incubation with or without MLS000544460 indicate that MLS000544460 is a reversible inhibitor with a slow off rate. Cpd, compound.
