Figure 2.
DNA methylation patterns in 8p11-p12-amplified tumors. The distribution of aberrant methylation (hyper- and hypomethylation, Q<0.05) and gene expression patterns (downregulation and upregulation, Q<0.01) among the 2066 differentially-methylated cytosine sites in 8p11-p12-amplified tumors. Transcripts were categorized into functional genomic regions (promoter region (between 200 and 1500 bp upstream of transcriptional start sites, 5′ untranslated region, first exon), gene body and 3′ untranslated region region) and regions surrounding CpG islands (CpG islands, 2 kb from CpG islands (CpG shores) and 2–4 kb from CpG islands (CpG shelves)).