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RAGE null mice displayed higher energy expenditure than WT mice. A: Food consumption was monitored at baseline and 3 and 6 weeks post-HFD. B–E: Mice were placed in metabolic chambers for assessment of VO2 (B), VCO2 (C), RER (D), and physical activity (E) at baseline, 3 weeks HFD, and 6 weeks HFD. The y-axes in all panels have an identical scale across the three time points. n = 6 mice/group.
