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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Circ Res. 2014 Mar 28;114(7):1185–1203. doi: 10.1161/CIRCRESAHA.114.301597

Figure 9. Enzymatic pathways that form oxidized phospholipids in platelets.

Figure 9

Panel A. Thrombin activation of protease activated receptors (PAR) triggers formation of HETE-PE and HETE-PCs, via several intracellular signaling cascades. Glutathione peroxidase (GPX) is required to reduce the initial hydroperoxide product to 12-HETE-PLs 26. Panel B. Formation of PGE2- and PGD2-PE in platelets following thrombin activation requires several intracellular signaling pathways, and most likely occurs in dense tubular membranes, where COX-1 has been localized35.