Fig 5. Enhanced levels of proinflammatory cytokines in CD4CreCtnnbex3 mice.
A. Dot plots showing frequencies of IL17 expressing CD4 T-cells in the indicated organs from wt and CD4CreCtnnbex3 mice. Note increased frequency of IL17 expressing CD4+ cells starts in SP thymocytes. B. Histograms showing the frequency of IL17 expressing CD4+ T-cells in the indicated organs from WT and CD4CreCtnnbex3 mice (n=3–8). C. Histograms showing quantification of the concentration of the indicated cytokines in lysates from the indicated parts of the intestine of WT versus CD4CreCtnnbex3 mice (n=3). Results are representative of two independent experiments. D. Histograms showing concentrations of the indicated cytokines in the serum of recipient Rag2−/− mice injected with 106 T-cells isolated from WT or CD4CreCtnnbex3 mice four weeks after transfer (n=3). Results are representative of two independent experiments.
