Figure 7. Comparative super-enhancer analysis of DLBCL cell lines and normal lymphoid tissue.
(A–D) Rank order of increasing integrated H3K27ac fold enrichment at enhancer loci in DLBCL cell lines, GCB (A), ABC (B) unclassified (C) and normal tonsil (D). (E) H3K27ac ChIP-Seq fold enrichment at the POU2AF1 locus showing the super-enhancer region. (F) H3K27ac ChIP-Seq reads at IRF4 locus in the 2 GCB and 2 ABC cell lines. (G) GSEA plot of the “UP_IN GCB_VS_PC” signature in five DLBCL cell lines following JQ1 treatment. (H) The leading edge genes of the GSEA in (G) were visualized as heatmap. (I) Similarity matrix from unsupervised hierarchical clustering of each cell line by location of super-enhancers. See also Table S7 and Figure S7.