Fig. 4.
Relative expression of a panel of angiogensis-related genes in RPE isolated from a healthy human donor eye (hRPE; set to 1) and CNV-RPE. Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2), VEGF-A, VEGF-C, fibroblast growth factor 2 (FGF2) and pigment epithelium derived factor (PEDF) are all expressed differentially in isolated CNV-RPE samples. However, expression of these factors is not directly linked to Sema3F expression changes displayed in Fig. 3C. These findings suggest that Sem3F expression changes are not secondary to changes in one of these known angiomodulatory factors.