Figure 2.
Intermittent fasting (IF) improves functional outcomes and reduces infarct size in male mice. (A) Three months of IF attenuates sensorimotor deficits after middle cerebral artery occlusion (MCAO). (B) Laser Doppler flowmetry shows no differences between groups in the extent to which MCAO compromises blood flow. (C) IF reduces infarct size in male C57Bl6J mice. (D) Staining for triphenyltetrazolium chloride (TTC) in 2-mm-thick brain sections taken after reperfusion reveals smaller infarcts in mice on the IF diet. Asterisk (*) indicates statistical significance at P<0.05 following t-test (C) or repeated measures analysis of variance (A, B). AL, ad libitum.