. 2012 Jun 25;33(8):1004–1012. doi: 10.1038/aps.2012.47

Table 2. Pretreatment with anti-OPN antibody 23C3 reduced ALT, histological necrosis, macrophage and neutrophil infiltration in WT mice 6 h after APAP administration. n=6 for each group. ^bP<0.05 compared to IgG-treated mice. ^*ND, Not done.

Treatment^a	ALT (IU/L)		Necrosis %		F4/80 positive cells per field		MPO (μmol/g tissue)
	IgG	23C3	IgG	23C3	IgG	23C3	IgG	23C3
Untreated	6±1	5.4±1.2	ND	ND	ND^*	ND	0.30±0.09	0.32±0.11
APAP	1440±80	870±120^b	23±4	18±4	37±5	22±3^b	0.75±0.18	0.35±0.15^b

Table 2. Pretreatment with anti-OPN antibody 23C3 reduced ALT, histological necrosis, macrophage and neutrophil infiltration in WT mice 6 h after APAP administration. n=6 for each group. bP<0.05 compared to IgG-treated mice. *ND, Not done.