TABLE 3.
Genetic factors that contribute to age-related hearing loss in inbred mouse strains
| AHL locus (gene) | Chr | Location | Mapping methods* | Known strains with susceptibility allele | Known strains with resistance allele | References |
|---|---|---|---|---|---|---|
| ahl(Cdh23) | 10 | 60 Mb | Backcross, strain haplotypes | Many | Many | (Johnson et al. 1997) (Johnson et al. 2000) (Noben-Trauth et al. 2003) |
| ahl4 (Cs) | 10 | 120–130 Mb | RI, CS strains backcross | A/J | C57BL/6J, CAST/Ei | (Zheng et al. 2009) (Johnson et al. 2012) |
| ahl5 (Gipc3) | 10 | 81 Mb | Backcross intercross | Black Swiss | CAST/Ei | (Drayton and Noben-Trauth 2006) (Charizopoulou et al. 2011) |
| ahl8 (Fscn2) | 11 | 120 Mb | RI strains backcross | DBA/2J | C57BL/6J | (Johnson et al. 2008) (Shin et al. 2010) |
| Gpr98, G protein coupled receptor 9 | 13 | 81 Mb | Backcross | BUB/BnJ | CAST/Ei | (Johnson et al. 2005) |
| mtDNA (mt-tr) | Mitochondria | Backcross | A/J | CAST/Ei | (Johnson et al. 2001) | |
CS chromosome substitution; RI recombinant inbred