Table 3.
Effect modification of ATP13A2 genotype on the association between manganese (Mn) in soil and motor function (Luria Nebraska Test).1
| Gene/ ATP13A2 | Coefficient2 (95% CI) | P-value interaction | Coefficient3 (95% CI) | P-value interaction |
|---|---|---|---|---|
| Elderly
| ||||
| rs4920608 | 0.029 | 0.032 | ||
| TT | −0.00057 (−0.0012; 0.0023) | 0.00044 (−0.0014; 0.0022) | ||
| CT | −0.0018 (−0.0029; −0.00061) | −0.0020 (−0.0032; −0.00085) | ||
| CC | −0.0025 (−0.0042; −0.00076) | −0.0024 (−0.0040; −0.00077) | ||
| rs2871776 | 0.041 | 0.046 | ||
| AA | 0.0010 (−0.0012; 0.0033) | 0.00073 (−0.0013; 0.0028) | ||
| AG | −0.0016 (−0.0027; −0.00047) | −0.0019 (−0.0030; −0.00071) | ||
| GG | −0.0022 (−0.0037; −0.00068) | −0.0022 (−0.0037; −0.00070) | ||
|
| ||||
| Adolescents
| ||||
| rs4920608 | 0.69 | 0.60 | ||
| TT | −0.0021 (−0.0036; 0.00060) | −0.0023 (−0.0038; −0.00073) | ||
| CT | −0.0013 (−0.0025; −0.000081) | −0.0012 (−0.0024; 0.000034) | ||
| CC | −0.0016 (−0.0039; 0.00071) | −0.0015 (−0.0038; 0.00080) | ||
| rs2871776 | 0.20 | 0.17 | ||
| AA | −0.0030 (−0.0048; −0.0012) | −0.0031 (−0.0049; −0.0013) | ||
| AG | −0.0011 (−0.0022; 0.00080) | −0.0011 (−0.0023; 0.00001) | ||
| GG | −0.0011 (−0.0030; 0.00070) | −0.00088 (−0.0029; 0.0011) | ||
1
The model was run for Motor function as outcome and with manganese in soil, genotype and a cross-product term for Mn in soil and genotype. The p-value for the cross term product is shown. In order to obtain effect estimates (beta-coefficients) for the effect of the genotypes, the analysis with motor function as outcome and Mn in soil as dependent variable (beta coefficient given) was run but stratified for the different genotypes.
2
Unadjusted analysis.
3
Analysis adjusted for age and gender.