Fig. 6.
Genetic loss of β6 integrin attenuates progression of lung fibrosis. TGF-α transgenic mice were mated with β6-null mice to test the effects of genetic β6 integrin inhibition at the initiation of lung fibrosis. Representative photomicrographs of lung tissues stained with Masson's trichrome comparing TGF-α transgenic mice in the presence or absence of the β6 integrin following 8 wk of Dox. Top, pleural regions of the lung; bottom, adventitia. Scale bar, 100 μm. Presented sections are representative of sections from 6–8 mice in each group.