Figure 3. NL3R451C Mutants Exhibit Increased Locomotor Activity.
(A) NL3R451C mice exhibited increased locomotor activity compared to WT mice in the open field test. (B) An increase in locomotor activity in the NL3R451C mice was also observed in the elevated plus maze (EPM). (C) Time spent in the center of an open field is increased in NL3R451C mice compared to WT mice. (D) Number of entries into the center of an open field area is also increased in NL3R451C mice. (E) There was no change in time spent in open arms of the EPM. (F) Time spent in closed arms of the EPM was unchanged between WT and NL3R451C mice. N=20 littermate pairs. **P<0.01 and ****P<0.0001