Skip to main content
. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Trends Immunol. 2014 Feb 21;35(4):144–152. doi: 10.1016/j.it.2014.01.002

Figure 1. MHC class I antigen presentation pathway.

Figure 1

Cellular proteins are degraded into oligopeptides by the ubiquitin-proteasome pathway. Most of these peptides are further degraded by peptidases into amino acids, but a small fraction are transferred into the lumen of the ER by the TAP-transporter, where they can be trimmed further into 8–10 amino acid fragments by the endoplasmic reticulum aminopeptidase-1 (ERAP-1). These peptides can then be bound by newly synthesized MHC class I and transported to the plasma membrane for display to CD8+ T cells.