Figure 3.
Hippocampal Volumes from Acute and Follow-up MRIs. A) Hyperintense hippocampi (Hyperintense; N=15) vs. hippocampi contralateral to them (Contralateral; N=13) and control hippocampi from FSE subjects with normal acute MRIs (FSE Controls; N=30). The number of hyperintense hippocampi is greater than the number of contralateral hippocampi because one subject had bilateral hyperintensity. Note that the hyperintense hippocampi lost approximately 20% of volume between the initial and follow up MRIs, whereas the contralateral and FSE control hippocampal volumes increased. The mixed linear model indicated that, at follow-up MRI. the mean volume of hyperintense hippocampi was less than the controls (p<0.0001) and the contralaterals (p=0.0001). At the baseline MRI, the mean volumes of the groups were not significantly different. B) Rt/Lt volume ratios of FSE subjects with normal acute MRIs were less than SFS subjects with normal acute MRIs (mean estimated Rt/Lt volume ratios of 0.98 vs. 1.03 respectively; F-test p=0.02). Rt/Lt ratios did not change significantly from baseline to follow-up MRIs (F test p=0.10). C) Right hippocampal volumes of FSE were less than SFS group by 171 and 262 mm3 at the acute and follow-up MRIs respectively (Bonferroni adjusted p=0.03 for acute and p <0.001 for follow-up). D) Left hippocampal volumes of FSE were less than SFS subjects by 82 and 162 mm3 at the acute and follow-up MRIs although these differences did not attain significance (Bonferroni adjusted p=0. 90 for acute and p= 0.07 for follow-up). From the acute to follow-up MRI, the volumes of both sides increased for SFS subjects (Bonferroni adjusted left side: p = 0.03; right side: p = 0.11). For FSE subjects, the slope of growth was flatter and volume change was not significant on either side (left side: p = 0.74; right side: p = 1.00). Bars are 95% confidence intervals. For B, C and D the groups were identical with FSEs (N=59) and SFS controls (N=38).